There is a start in goal for Kepa Arrizabalaga tonight as Thomas Tuchel makes seven changes from the side that won at Man City.
Mason Mount and Ben Chilwell, rested for that game, also return, as do Jorginho and Kai Havertz.
Thiago Silva comes into defence for injured Andreas Christensen and Kurt Zouma for Toni Rudiger who is on the bench.
Willian, on his first return to Stamford Bridge with the Gunners, is on the bench. David Luiz is ruled out through injury.
Overall the Gunners make five changes. Mari, Partey, Tierney, Odegaard and Aubameyang come in for Chambers, Ceballos, Pepe, Martinelli plus Willian.
Chelsea: Kepa; Azpilicueta (c), Thiago Silva, Zouma; James, Gilmour, Jorginho, Chilwell; Mount, Havertz, Pulisic.
Substitutes: Mendy, Alonso, Emerson, Hudson-Odoi, Livramento, Anjorin, Ziyech, Giroud, Werner.
Arsenal: Leno; Holding, Gabriel, Mari, Tierney, Elneny, Partey, Saka, Odegaard, Smith Rowe, Aubameyang (c).
Subs: Ryan, Bellerin, Chambers, Ceballos, Soares, Pepe, Lacazette, Willian, Martinelli.
The referee is Andre Marriner.